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One of the most effective anti-nausea medications is Zofran (ondansetron) which was developed to solve this problem. Drug Group: 5-HT3-Receptor Antagonist: First-generation antihistamine: Active Therapeutic Agent: Ondansetron HCL: Promethazine: Onset of Action. Most people for the record are given Phenergan or promethazine Tablets first and if that does not work they got to the Zofran not only for more effect but the Zofran is much more expensive than the Phenergan. While Phenergan contains Promethazine which is Antihistamine and also act ant vomiting agent Dose of Zofran for Nausea 4-8 mg It is taken by mouth every 6 hours, as needed While it is safe for the general population, it is so effective, that it is also used in patients undergoing chemotherapy. 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While it is safe for the general population, it is so effective, that it is. At 30 and 60 minutes, VAS symptom ratings for prochlorperazine were significantly better than for promethazine (20 vs 46 mm, P = 0. North American Dental Group (NADG), based in Pittsburgh, Pennsylvania, was co-founded in 2008 by Ken Cooper and Dr.. At OHSU, he was elected as a Fellow of the gastrointestinal treatment zofran, the University of Oregon Health Sciences Center in 1978. Complete relief at 30 minutes was achieved in 33% of. I have nausea/vomitting almost immediately after eating. Zofran: Phenergan: Zofran is the 5-HT3-Receptor Antagonis, which is used to treat nausea and vomiting. We use Zofran, Phenergan, and low dose Ativan for nausea. Analyses included t-tests, tests for proportions, and 95% confidence intervals (CIs). 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